منابع مشابه
Polyglutamylation of nucleosome assembly proteins.
Polyglutamylation is an original posttranslational modification, discovered on tubulin, consisting in side chains composed of several glutamyl units and leading to a very unusual protein structure. A monoclonal antibody directed against glutamylated tubulin (GT335) was found to react with other proteins present in HeLa cells. After immunopurification on a GT335 affinity column, two prominent pr...
متن کاملNucleosome assembly and genome integrity
Maintaining the stability of the replication forks is one of the main tasks of the DNA damage response. Specifically, checkpoint mechanisms detect stressed forks and prevent their collapse. In the published report reviewed here we have shown that defective chromatin assembly in cells lacking either H3K56 acetylation or the chromatin assembly factors CAF1 and Rtt106 affects the integrity of adva...
متن کاملAssembly and disassembly of nucleosome core particles containing histone variants by human nucleosome assembly protein I.
Histone variants play important roles in the maintenance and regulation of the chromatin structure. In order to characterize the biochemical properties of the chromatin structure containing histone variants, we investigated the dynamic status of nucleosome core particles (NCPs) that were assembled with recombinant histones. We found that in the presence of nucleosome assembly protein I (NAP-I),...
متن کاملHistone variants, nucleosome assembly and epigenetic inheritance.
Template copying is the basis for inheritance and specification of genetic information and for the propagation of DNA methylation. However, no templating machinery has been identified that is capable of propagating histone modifications and conformations. Potential solutions to this enigma come from recent insights into histone variants and the specialized complexes that assemble them into nucl...
متن کاملThe structure of nucleosome assembly protein 1.
Nucleosome assembly protein 1 (NAP-1) is an integral component in the establishment, maintenance, and dynamics of eukaryotic chromatin. It shuttles histones into the nucleus, assembles nucleosomes, and promotes chromatin fluidity, thereby affecting the transcription of many genes. The 3.0 A crystal structure of yeast NAP-1 reveals a previously uncharacterized fold with implications for histone ...
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ژورنال
عنوان ژورنال: Structure
سال: 2004
ISSN: 0969-2126
DOI: 10.1016/j.str.2004.11.004